Classification of pathology in diabetic eye disease

Proliferative diabetic retinopathy is a complication of diabetes that can eventually lead to blindness. Early identification of this complication reduces the risk of blindness by initiating timely treatment. We report the utility of pattern analysis tools linked with a simple linear discriminant analysis that not only identifies new vessel growth in the retinal fundus but also localises the area of pathology. Ten fluorescein images were analysed using seven feature descriptors including area, perimeter, circularity, curvature, entropy, wavelet second moment and the correlation dimension. Our results indicate that traditional features such as area or perimeter measures of neovascularisation associated with proliferative retinopathy were not sensitive enough to detect early proliferative retinopathy (SNR = 0.76, 0.75 respectively). The wavelet second moment provided the best discrimination with a SNR of 1.17. Combining second moment, curvature and global correlation dimension provided a 100% discrimination (SNR = 1)

Comparison of various methods to delineate blood vessels in retinal images

The blood vessels in the human retina are easily visualisable via digital fundus photography and provide an excellent window to the health of a patient affected by diseases of blood circulation such as diabetes. Diabetic retinopathy is identifiable through lesions of the vessels such as narrowing of the arteriole walls, beading of venules into sausage like structures and new vessel growth as an attempt to reperfuse ischaemic regions. Automated quantification of these lesions would be beneficial to diabetes research and to clinical practice, particularly for eye-screening programmes for the detection of eye-disease amongst diabetic persons

Development of retinal blood vessel segmentation methodology using wavelet transforms for assessment of diabetic retinopathy

Automated image processing has the potential to assist in the early detection of diabetes, by detecting changes in blood vessel diameter and patterns in the retina. This paper describes the development of segmentation methodology in the processing of retinal blood vessel images obtained using non-mydriatic colour photography. The methods used include wavelet analysis, supervised classifier probabilities and adaptive threshold procedures, as well as morphology-based techniques. We show highly accurate identification of blood vessels for the purpose of studying changes in the vessel network that can be utilized for detecting blood vessel diameter changes associated with the pathophysiology of diabetes. In conjunction with suitable feature extraction and automated classification methods, our segmentation method could form the basis of a quick and accurate test for diabetic retinopathy, which would have huge benefits in terms of improved access to screening people for risk or presence of diabetes